{"id":2778,"date":"2018-09-21T11:05:45","date_gmt":"2018-09-21T09:05:45","guid":{"rendered":"http:\/\/bliss.pro\/fracture\/?p=2778"},"modified":"2018-09-21T11:05:45","modified_gmt":"2018-09-21T09:05:45","slug":"%ec%9d%b4%ed%8b%80-%ec%a0%84-%ec%88%98%ec%84%9d%c2%b7%eb%b3%b4%ec%a2%8c%ea%b4%80%ed%9a%8c%ec%9d%98%ec%97%90%ec%84%9c-%eb%8c%80","status":"publish","type":"post","link":"https:\/\/bliss.pro\/fracture\/%ec%9d%b4%ed%8b%80-%ec%a0%84-%ec%88%98%ec%84%9d%c2%b7%eb%b3%b4%ec%a2%8c%ea%b4%80%ed%9a%8c%ec%9d%98%ec%97%90%ec%84%9c-%eb%8c%80\/","title":{"rendered":"\uc774\ud2c0 \uc804 \uc218\uc11d\u00b7\ubcf4\uc88c\uad00\ud68c\uc758\uc5d0\uc11c \u00ab\u00a0\ub300"},"content":{"rendered":"

\uc774\ud2c0 \uc804 \uc218\uc11d\u00b7\ubcf4\uc88c\uad00\ud68c\uc758\uc5d0\uc11c \u00ab\u00a0\ub300\ud654\uc758 \ubb3c\uaf2c\uac00 \ud2b8\uc774\uace0 (\ubd81\ubbf8) \ub450 \uc815\uc0c1\uc774 \ub2e4\uc2dc \ub9c8\uc8fc \uc549\ub294\ub2e4\uba74 \ube44\ud575\ud654 \ubb38\uc81c\uac00 \ube60\ub978 \uc18d\ub3c4\ub85c \uc9c4\ucc99\ub420 \uc218 \uc788\uc73c\ub9ac\ub77c \ubbff\ub294\ub2e4\u00a0\u00bb\uace0 \uac15\uc870\ud55c \ubb38 \ub300\ud1b5\ub839\uc5d0\uac8c\ub294 \uace0\ubb34\uc801\uc778 \ubc18\uc751\uc774\ub2e4. \uc7ac\uacc4\uc5d0\uc11c\ub294 \uc7ac\uacc4 1\uc704 \uc0bc\uc131\uc758 \ucd1d\uc218\uac00 \ub300\ud1b5\ub839 \uacbd\uc81c\ubcf4\uc88c\uad00\uacfc \uc5b4\ub5a4 \ub300\ud654\ub97c \ub098\ub234\uc744\uc9c0\uc5d0 \uad00\uc2ec\uc744 \uae30\uc6b8\uc774\uace0 \uc788\ub2e4.. \uc774\uc640 \uad00\ub828\ud574 \ub300\uc804\uc18c\ubc29\ubcf8\ubd80 \uad00\uacc4\uc790\ub294 \u00ab\u00a0\ub9f9\uc218\ub958 \ud0c8\ucd9c \uc6d0\uc778\uc774 \ub300\ubd80\ubd84 \uad00\ub9ac\uc18c\ud640\uc778 \ub9cc\ud07c \uc0ac\uc721\uc0ac\uc5d0 \ub300\ud55c \uad50\uc721\uc744 \uac15\ud654\ud558\uace0 \uc6b0\ub9ac\uc5d0 \uc548\uc804\uc7a5\uce58\ub97c \uc124\uce58\ud558\ub294 \ub4f1 \ub300\ucc45\uc744 \ub9c8\ub828\ud574\uc57c\ud560 \uac83\u00a0\u00bb\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4. <\/p>\n

\uc544\uc6b8\ub7ec \ubb38 \ub300\ud1b5\ub839\uacfc \uae40 \uc704\uc6d0\uc7a5\uc758 \ubc30\uc11d\uc790 \uc5c6\ub294 \ub3c5\ub300\uac00 70\ubd84\uac04 \uacc4\uc18d\ub41c \ub9cc\ud07c, \uc120\uc5b8\ubb38\uc5d0 \ub2f4\uae30\uc9c0 \uc54a\uc740 \ube44\ud575\ud654 \uad00\ub828 \ub17c\uc758\uac00 \uc2ec\ub3c4 \uc788\uac8c \uc9c4\ud589\ub410\ub2e4\ub294 \ucd94\uc815\uc774 \uac00\ub2a5\ud558\ub2e4. \uc77c\uac01\uc5d0\uc11c\ub294 \uc774\uc0b0\uac00\uc871\uba74\ud68c\uc18c\ub97c ‘\uc0c1\uc124\uba74\ud68c\uc18c’\ub77c\uace0 \uc774\ub984 \ubd99\uc778 \uac83\ub3c4 \ud5a5\ud6c4 \uc774\uc0b0\uac00\uc871 \uc0c1\ubd09 \uc815\ub840\ud654\uc640 \uad00\ub828\ud55c \ub0a8\ubd81 \uc815\uc0c1\uc758 \uc758\uc9c0\ub97c \ubc18\uc601\ud55c \uac83\uc774\ub77c\ub294 \ubd84\uc11d\uc744 \ub0b4\ub193\uace0 \uc788\ub2e4. (\ud64d\ucf69=\uc5f0\ud569\ub274\uc2a4) \uc548\uc2b9\uc12d \ud2b9\ud30c\uc6d0 = \ubbf8\uad6d, \uc720\ub7fd, \uce90\ub098\ub2e4, \ud638\uc8fc, \uc77c\ubcf8 \ub4f1 \uc138\uacc4 \uac01\uad6d\uc774 \uad6d\uac00\uc548\ubcf4\ub97c \uc774\uc720\ub85c \uc911\uad6d \uc790\ubcf8\uc758 \uc790\uad6d \uae30\uc220\uae30\uc5c5 \uc778\uc218\uc5d0 \ube57\uc7a5\uc744 \uac78\uc5b4 \uc7a0\uadf8\uace0 \uc788\ub2e4\uace0 \ud64d\ucf69 \uc0ac\uc6b0\uc2a4\ucc28\uc774\ub098\ubaa8\ub2dd\ud3ec\uc2a4\ud2b8(SCMP)\uac00 14\uc77c \ubcf4\ub3c4\ud588\ub2e4. <\/p>\n

\ud0c8\ucd9c\ud55c \ud4e8\ub9c8\uac00 \uc790\uce6b \uc2dc\ubbfc\uc758 \uc548\uc804\uc744 \uc704\ud611\ud560 \uc218 \uc788\ub294 \uc0c1\ud669\uc5d0\uc11c ‘\ubd88\uac00\ud53c\ud55c \ucd5c\uc120\uc758 \uc120\ud0dd’\uc774\uc5c8\ub2e4\uace0 \ucf5c\uac78<\/a> \uaddc\uc815\ud558\uba70 \uc77c\ubd80\uc5d0\uc11c \uc81c\uae30\ub418\ub294 \uacfc\uc789\ub300\uc751 \ub17c\ub780\uc744 \ucc28\ub2e8\ud558\uae30 \uc704\ud55c \uc758\ub3c4\ub85c \ud480\uc774\ub41c\ub2e4. \uc720 \uc804 \uc5f0\uad6c\uad00\uc740 \uc11c\uc6b8\uc911\uc559\uc9c0\uac80 \uc218\uc0ac\ud300(\ud55c\ub3d9\ud6c8 3\ucc28\uc7a5\uac80\uc0ac)\uc774 \uc0ac\ubc95\ud589\uc815\uad8c \ub0a8\uc6a9 \uc758\ud639\uc744 \uc218\uc0ac\ud55c \uc9c0 \uc11d \ub2ec \ub9cc\uc5d0 \ucc98\uc74c\uc73c\ub85c \uc2e0\ubcd1\ud655\ubcf4\uc5d0 \ub098\uc120 \ud53c\uc758\uc790\ub2e4. \uc5b4\ub5a4 \uc2e0\uc778\ub3c4 \ub85c\ud398\uc2a4\uac00 \uc774\ub8ec \uc131\uacfc\ub97c \ub6f0\uc5b4\ub118\uc9c0 \ubabb\ud588\ub2e4. \uacfc\uac70 \uae40\ub300\uc911\u00b7\ub178\ubb34\ud604 \uc804 \ub300\ud1b5\ub839\uc758 \ubc29\ubd81 \ub54c\uc640 \ube44\uad50\ud558\uba74 \ub208\uc5d0 \ub744\ub294 ‘\ubc00\ucc29 \ud589\ubcf4’\uc600\ub2e4. <\/p>\n

\ud22c\ubc15\ud55c \uc60c\ubcdc\uc0ac\ud22c\ub9ac\ub294 \uc61b\ub9d0\uc774\uace0 \ubcc0\ud638\uc0ac\u00b7\uc758\uc0ac \ub4f1 \uc804\ubb38\uc9c1 \uc885\uc0ac\uc790\ub4e4\ub3c4 \uac10\ucabd\uac19\uc774 \ub2f9\ud558\ub294 \uc2e4\uc815\uc774\ub77c\uace0 \ud55c\ub2e4. \ucc9c\uc548\u00b7\uc544\uc0b0 \ub4f1 \uadfc\ucc98 \ub3c4\uc2dc\ubcf4\ub2e4 \uba40\ub9ac \uc11c\uc6b8\u00b7\uacbd\uae30 \ub4f1 \uc678\uc9c0\uc778\ub4e4\uc774 \ucc3e\uc544\uc624\ub294 \ube44\uc728\ub3c4 \ud6e8\uc52c \ub192\uc544\uc84c\ub2e4. \uc790\uad6d\uc5d0\uc11c \uc0dd\uc0b0\ub418\ub294 \uc77c\ubd80 \uc81c\ud488\uc758 \ubbf8\uad6d \uc218\ucd9c\uc744 \uae08\uc9c0\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubcf4\ubcf5 \ubc29\uc548\uc744 \ub0b4\ub193\uc744 \uc218 \uc788\ub2e4\ub294 \ubc1c\uc5b8\ub3c4 \ub098\uc654\ub2e4. \u00ab\u00a0\uad6d\uac00\uc801\uc73c\ub85c\ub098 \uc0ac\ud68c\uc801\uc73c\ub85c \ub300\ub2e8\ud788 \uc624\ud53c\uac78<\/a> \uc911\uc694\ud55c \uc0ac\uc548\uc740 \ucc98\uc74c\ubd80\ud130 \uc5ec\ub7ec \ubd80\uc11c\uac00 \ud568\uaed8 \ub17c\uc758\ud574 \uc9c0\ud61c\ub97c \ubaa8\uc73c\uba74 \uc88b\uc558\uc744 \ud150\ub370 \uadf8\ub7ec\uc9c0 \uc54a\uc558\ub2e4\u00a0\u00bb\ub294 \uac83\uc774\ub2e4. \u25b2 \uc62c\ud574 \uc5f0\ub9d0\uc774 \uac1c\uc131\uacf5\ub2e8\uc5d0 \uc785\uc8fc\ud588\ub358 \uae30\uc5c5\ub4e4\uc774 \ubc84\ud2f8 \uc218 \uc788\ub294 \ud55c\uacc4\ub2e4. <\/p>\n

These new findings suggest that pretreatment with these two agents could promote and \ucf5c\uac78<\/a> enhance tumor cell killing activity by MEN1112\/OBT357, and provide a strong rationale for evaluating these combinations in clinical trial.\u00a0\u00bb. \ub0a8\ubd81\uacf5\ub3d9\ubc1c\uad74\uc870\uc0ac 6\uac1c\uc6d4\ub9cc\uc5d0 \uc885\ub8cc\u2026\uc720\ubb3c 3\ucc9c500\uc5ec\uc810 \ucd9c\ud1a0(\uc11c\uc6b8=\uc5f0\ud569\ub274\uc2a4) \uace0\uc740\uc9c0 \uae30\uc790 = \ub0a8\ubd81\uc774 \uc9c0\ub09c 6\uac1c\uc6d4\uac04 \uac1c\uc131 \ub9cc\uc6d4\ub300 \uc9c0\uc5ed\uc744 \ub300\uc0c1\uc73c\ub85c \uc2dc\ud589\ud55c \uc81c7\ucc28 \uacf5\ub3d9\ubc1c\uad74\uc870\uc0ac\uc5d0\uc11c \uace0\ub824\uc2dc\ub300\uc758 \uac83\uc73c\ub85c \ucd94\uc815\ub418\ub294 \uae08\uc18d\ud65c\uc790\uac00 \ucd9c\ud1a0\ub410\ub2e4. <\/p>\n

\uac00\uc7a5 \uc88b\uc740 \ubc29\ubc95\uc740 \ucd08\uc911\uace0\uad50\uc5d0\uc11c \uc601\ud654\uac00 \uc815\uaddc\uacfc\ubaa9\uc5d0 \ub4e4\uc5b4\uac00\ub294 \uac83\uc774\ub2e4. [\ud45c] \ucd94\uc11d \uc5f0\ud734\uc5d0 \ucd9c\uc7a5\uc544\uac00\uc528<\/a> \ubb38\uc744 \uc5ec\ub294 \ubcd1\u00b7\uc758\uc6d0 \ubc0f \uc57d\uad6d \uc218. \uc774\ub0a0 \uc800\ub141 \ubb38 \ub300\ud1b5\ub839\uc774 \ubd81\ud55c \uc815\uad8c\uc218\ub9bd 70\uc8fc\ub144\uc744 \ub9de\uc544 \uacf5\uc5f0 \uc911\uc778 \uc9d1\ub2e8\uccb4\uc870\ub97c \uad00\ub78c\ud558\ub294 \uc790\ub9ac\uc5d0\uc11c\ub294 15\ub9cc\uba85\uc758 \ubd81\ud55c \uad00\ub78c\uac1d\uc5d0\uac8c \uc778\uc0ac\ub9d0\uc744 \ud560 \uc608\uc815\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4. 6\u00b725\uc804\uc7c1\uc774 \ub05d\ub098\uace0 \uad6d\ud1a0 \uc7ac\uac74\uc774 \ud55c\ucc3d\uc77c \ub54c\uc600\ub2e4. \uc655\ubcf5 2\ucc28\uc120 \uc591\ucabd\uc5d0 \ud55c \uc9d1 \uac74\ub108 \ud55c \uc9d1\uc774 \uc21c\ub300 \uc2dd\ub2f9\uc73c\ub85c \ub4e4\uc5b4\ucc28 \uc788\ub2e4. \uc6b0\ubc84 \uc0ac\uc6a9\uc790\uc5d0\uac8c\ub294 \ud754\ud55c \uc77c\uc785\ub2c8\ub2e4. <\/p>\n

\u00ab\u00a0\uc5f0\uae30\ud558\ub294 \ucf8c\uac10 \ucee4\u2026\uacc4\uc18d \uc77c\ud560 \uc218 \uc788\uc5b4\uc11c \uac10\uc0ac\ud558\ub2e4\u00a0\u00bb (\uc11c\uc6b8=\uc5f0\ud569\ub274\uc2a4) \uc774\ub3c4\uc5f0 \uae30\uc790 = \u00ab\u00a0\uc131\ud615\uc744 \ud588\ub4e0\uc9c0 \uc548 \ud588\ub4e0\uc9c0 \ub0a8\uc758 \uc678\ubaa8\uc5d0 \ucc38\uacac\ud558\ub294 \uc77c\uc740 \ud3ed\ub825\uc801\uc774\uace0 \ubb34\ub840\ud55c \uac83\uc774\ub77c \uc0dd\uac01\ud574\uc694.\u00a0\u00bb 19\uc77c \uc11c\uc6b8 \uc885\ub85c\uad6c \uc0bc\uccad\ub3d9\uc5d0\uc11c \ub9cc\ub09c \ubc30\uc6b0 \uacfd\ub3d9\uc5f0(21)\uc740 \ucd5c\uadfc \uc885\uc601\ud55c JTBC \uae08\ud1a0\uadf9 ‘\ub0b4 \uc544\uc774\ub514\ub294 \uac15\ub0a8\ubbf8\uc778’\uc5d0\uc11c \uadf8\uac00 \ub9e1\uc740 \uc5f0\uc6b0\uc601 \uc5ed\uacfc \ub2ee\uc544\uc788\uc5c8\ub2e4. \ucd5c\ub300 4\uba85\uae4c\uc9c0 \ub3d9\uc2dc \ud544\uae30\uac00 \uac00\ub2a5\ud55c \uc0bc\uc131 \ud50c\ub9bd\uc740 \ubc14\ud034\uac00 \ub2ec\ub9b0 \uc774\ub3d9\uc2dd \uc2a4\ud0e0\ub4dc\ub85c \uc7a5\uc18c\ub97c \uc62e\uae38 \uc218\ub3c4 \uc788\ub2e4. \uc800\uc790\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc88b\uc740 \ud3c9\ud310\uc744 \uc5bb\uae30 \uc704\ud574 \uc2e4\ub825\uc744 \uc313\uace0 \ub178\ub825\ud558\uc9c0\ub9cc, \uce58\ubc00\ud55c \uc804\ub7b5\uc774 \ub3d9\ubc18\ub418\uc9c0 \uc54a\uc73c\uba74 \ubb34\uc6a9\uc9c0\ubb3c\uc774\ub77c\uace0 \ub9d0\ud55c\ub2e4. <\/p>\n

\ud604\uc7ac \uc2dc\ub9ac\uc544 \uc815\ubd80\ub294 \ub0b4\uc804 \uc774\uc804 \uc2dc\ub9ac\uc544 \uc601\ud1a0\uc758 3\ubd84\uc758 2\uac00\ub7c9\uc744 \ud1b5\uc81c\ud55c\ub2e4. KBS\ub294 \uc9c0\ub09c 4\u00b727 \ud310\ubb38\uc810 \uc815\uc0c1\ud68c\ub2f4\uc5d0 \uc774\uc5b4 \uc774\ubc88 \ud3c9\uc591 \ucd9c\uc7a5\uc0f5\ucd94\ucc9c<\/a> \uc815\uc0c1\ud68c\ub2f4\uc5d0\uc11c\ub3c4 \uc8fc\uad00\ubc29\uc1a1\uc0ac\ub85c\uc11c\uc758 \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc810\uc744 17\uc77c \uac15\uc870\ud588\ub2e4. \uc8fc 52\uc2dc\uac04 \uadfc\ubb34\uc81c\uac00 \uace0\uc6a9\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0\ub3c4 \ubd84\uc11d\ud574 \ud544\uc694\ud558\ub2e4\uba74 \ubcf4\uc644\ud574\uc57c \ud55c\ub2e4. 2005\ub144 \uc124\ub9bd\ub41c \uc774\ud6c4 7\uba85\uc774 \uc0ac\uc7a5\uc744 \ub9e1\uc558\uc73c\ub098 \ub0b4\ubd80 \uc9c1\uc6d0 \ucd9c\uc2e0\uc740 \ucd08\ub300\uc0ac\uc7a5 \ube7c\uace0\ub294 \uc5c6\ub2e4. \uae40\uad11\uc2dd \uac10\ub3c5\uc740 \uc18c\ub144 \uc5ed\ud560\uc744 \ud560 \ubc30\uc6b0\ub97c \ubb3c\uc0c9\ud558\ub2e4 \uadf8\ub97c \ub099\uc810\ud588\ub2e4\uace0 \ud55c\ub2e4.. <\/p>\n

\ub2c8\ud0a4 \ud5e4\uc77c\ub9ac \uc720\uc5d4\uc8fc\uc7ac \ubbf8\uad6d \ub300\uc0ac\ub294 \uc774\ub0a0 \ub274\uc695 \uc720\uc5d4\ubcf8\ubd80\uc5d0\uc11c ‘\ube44\ud655\uc0b0 \ubc0f \ubd81\ud55c’\uc744 \uc8fc\uc81c\ub85c \uc5f4\ub9b0 \uc548\ubcf4\ub9ac \ud68c\uc758\uc5d0\uc11c \ub7ec\uc2dc\uc544\uc758 \uc9c0\uc18d\uc801\uc774\uace0 \uad11\ubc94\uc704\ud55c \uc81c\uc7ac\uc704\ubc18 \uc99d\uac70\uac00 \uc788\ub2e4\uba74\uc11c \ubd81\ud55c\uc774 \ubd88\ubc95\uc801\uc73c\ub85c \uc815\uc720\uc81c\ud488\uc744 \ud68d\ub4dd\ud558\ub3c4\ub85d \ub3d5\uace0 \uc788\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ub09a\uc2dc \ub4f1\uc5d0 \uad00\uc2ec\uc744 \ub454 \uc774\ub4e4\uc740 \uce74\uc57d\uc744 \uc774\uc6a9\ud55c \uce74\uc57d\ucea0\ud551\uc5d0 \ube60\uc9c0\uae30\ub3c4 \ud588\uace0, \uacbd\uc81c\ub825\uc774 \ub418\ub294 \uc0ac\ub78c\ub4e4\uc740 \uc9c4\uc815\ud55c \uc758\ubbf8\uc758 \uc624\ud1a0\ucea0\ud551\uc5d0 \ube60\uc838\ub4e4\uc5c8\ub2e4. \ub3c5\ub9bd\uc6b4\ub3d9\uac00\ub4e4\uc774 \uc0c1\ud574 \uc784\uc2dc\uc815\ubd80\ub97c \uc138\uc6b4 \uc9c0 \uc5b4\uc5b8 1\uc138\uae30\uac00 \uc9c0\ub09c \uc9c0\uae08, \ubbf8\ub798\ub85c \ub098\uc544\uac00\uae30 \uc704\ud574\uc11c\ub77c\ub3c4 \uc9c0\ub09c \uc138\uae30\ub97c \uacb8\ud5c8\ud788 \ub418\ub3cc\uc544\ubd10\uc57c \ud55c\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

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